Located in western North Carolina, this is one of my favorite locations in the state.
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Biltmore Estate: No trip to Asheville is complete without a trip to Biltmore! The summer home of George Vanderbilt, completed in 1895, is a must see. It's the largest private home in the United States (over 175,000 sq. ft.)! A movie, The Private Eyes (think Clue board game) with Don Knotts, was filmed here in 1980.
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Thomas Wolfe Memorial: The home of the author is now a tourist attraction. The genius (enrolled for class at the University of North Carolina at age 15) was born in 1900 and died in 1937 of tubercular meningitis of the brain.
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Nosh:
Bistro (at Biltmore Estate): There are many dining options on the property and the menu at most of them change regularly. Halibut with bacon, shrimp, and asparagus.
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Nip:
New Belgium Brewery: Yes, they now have an east coast brewery. The original is in Fort Collins, Colorado.
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Biltmore Estate Winery: They make wine with grapes grown on the property and water from the French Broad River. The master vintner (when I was there) was from France. The wine is definitely good but doesn't have the depth of flavor as California dry wines.